From direction A7:
Take exit 29 towards HH-Othmarschen, follow signs for Elbbrücken / Zentrum / Altona, follow Walderseestrasse and then Behringstrasse. Turn right to Hohenzollernring, turn left to Elbchaussee and follow Klopstockstraße. Turn right into Kaistraße, then left into Grosse Elbstrasse. Turn right onto Van-der-Smissen-Straße and follow the signs for the Cruise Center Altona.
From direction A1 / A255 / A252 / B4 / B75:
After the Elbbrücken (Billhorner Brückenstraße) take the exit direction Freihafen / HafenCity. Follow Zweibrückenstraße, Versmannstraße and Überseeallee to Osakaallee. Keep left: At Sandtorkai turn left towards Baumwall (or take the path as indicated). Pass Landungsbrücken, the St. Pauli Hafenstraße and the St. Pauli Fischmarkt. Then follow the signs for the Cruise Center Altona or follow the Breite Straße, Palmaille-Kaistraße and Große Elbstraße to Edgar-Engelhard-Kai.
From direction A24:
Follow the A24 to Hammer Kreisel - Sievekingsallee - Bürgerweide. Turn left into Heidenkampsweg, turn right into Bergfelderstraße. Drive towards Deichtorhallen, follow the Willy Brandt-Straße and the Reeperbahn, turn left to Pepermölenbek. Follow the signs for Cruise Center Altona or follow the Breite Straße, Palmaille-Kaistraße and Große Elbstraße to Edgar-Engelhard-Kai.